SUBSTANCE: Aldactone (Spironolactone)
PACK: 25mg 30 pills
Potassium, magnesium-saving diuretic. It is a competitive antagonist of aldosterone on the effect on the distal sections of the nephron (competes for binding sites on cytoplasmic protein receptors, reduces the synthesis of permeases in the aldosterone-dependent region of the collecting tubules and distal tubules), increases the excretion of Na +, Cl- and water and reduces the excretion of K + and urea, Reduces the titratable acidity of urine. Strengthening diuresis causes a hypotensive effect, which is unstable. The hypotensive effect does not depend on the level of renin in the blood plasma and does not appear with normal blood pressure.
Nausea, vomiting, abdominal pain, gastritis, ulceration and bleeding in the digestive tract, intestinal colic, diarrhea or constipation, dizziness; Drowsiness, lethargy, headache, inhibition, ataxia, muscle spasms, decreased potency, increased urea concentration, hypercreatininaemia, hyperuricemia, water-salt metabolism and CBS (metabolic hypochloraemic acidosis or alkalosis); Megaloblasticosis, agranulocytosis, thrombocytopenia.
During treatment should avoid excessive intake of potassium in the body. It is not recommended to combine with other potassium-sparing diuretics. At simultaneous appointment with hypotensive and diuretic means it is necessary to reduce doses.